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Epithelioid sarcoma or malignant rhabdoid tumor of soft tissue? Epithelioid immunophenotype and rhabdoid karyotype.

Authors :
Molenaar WM
DeJong B
Dam-Meiring A
Postma A
DeVries J
Hoekstra HJ
Source :
Human pathology [Hum Pathol] 1989 Apr; Vol. 20 (4), pp. 347-51.
Publication Year :
1989

Abstract

Two children and one young adult with extremity sarcomas demonstrating an aggressive clinical behavior are described. Histologically, all three tumors displayed features compatible with a deep-seated epithelioid sarcoma or with a malignant rhabdoid tumor of soft tissue. Immunohistologically, both vimentin and epithelial antigens were demonstrated; however, no desmin was detectable. In all three cases, the DNA profile was diploid. In one case, a trisomy of chromosome 2 was found in the tumor cells, a phenomenon also observed in embryonal rhabdomyosarcomas. It is concluded that, although the immunohistologic findings support the epithelioid character of the tumors, this chromosomal finding suggests a relationship with rhabdomyosarcomas and justifies the designation of rhabdoid.

Details

Language :
English
ISSN :
0046-8177
Volume :
20
Issue :
4
Database :
MEDLINE
Journal :
Human pathology
Publication Type :
Academic Journal
Accession number :
2649435
Full Text :
https://doi.org/10.1016/0046-8177(89)90044-0