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Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice.
- Source :
-
Science (New York, N.Y.) [Science] 2015 Nov 20; Vol. 350 (6263), pp. 957-61. Date of Electronic Publication: 2015 Oct 22. - Publication Year :
- 2015
-
Abstract
- Mammalian sleep comprises rapid eye movement (REM) sleep and non-REM (NREM) sleep. To functionally isolate from the complex mixture of neurons populating the brainstem pons those involved in switching between REM and NREM sleep, we chemogenetically manipulated neurons of a specific embryonic cell lineage in mice. We identified excitatory glutamatergic neurons that inhibit REM sleep and promote NREM sleep. These neurons shared a common developmental origin with neurons promoting wakefulness; both derived from a pool of proneural hindbrain cells expressing Atoh1 at embryonic day 10.5. We also identified inhibitory γ-aminobutyric acid-releasing neurons that act downstream to inhibit REM sleep. Artificial reduction or prolongation of REM sleep in turn affected slow-wave activity during subsequent NREM sleep, implicating REM sleep in the regulation of NREM sleep.<br /> (Copyright © 2015, American Association for the Advancement of Science.)
- Subjects :
- Animals
Basic Helix-Loop-Helix Transcription Factors genetics
Basic Helix-Loop-Helix Transcription Factors metabolism
Brain Stem cytology
Brain Stem physiology
Cell Lineage
Cell Separation
Female
Glutamates metabolism
Male
Mice
Mice, Transgenic
Neurons metabolism
Pons cytology
Pons physiology
gamma-Aminobutyric Acid
Neurons physiology
Rhombencephalon cytology
Rhombencephalon embryology
Sleep, REM physiology
Wakefulness physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 350
- Issue :
- 6263
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 26494173
- Full Text :
- https://doi.org/10.1126/science.aad1023