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Genetic and environmental contributions to initiation of cigarette smoking in young African-American and European-American women.
- Source :
-
Drug and alcohol dependence [Drug Alcohol Depend] 2015 Dec 01; Vol. 157, pp. 54-9. Date of Electronic Publication: 2015 Oct 16. - Publication Year :
- 2015
-
Abstract
- Background: Distinctions in the relative contributions of genetic and environmental factors to initiation of cigarette smoking may explain, in part, the differences between African Americans and European Americans in the prevalence of smoking. The current investigation is the first to compare heritable and environmental influences on smoking initiation between African-American and European-American women.<br />Methods: Data were drawn from Missouri Adolescent Female Twin Study participants and female Missouri Family Study participants (n=4498; 21% African-American, the remainder European-American). Mean ages at first and last assessments were 17.0 (SD=3.5) and 24.0 (SD=3.2), respectively. Twin-sibling modeling was conducted to estimate the proportion of variance in smoking initiation (i.e., ever trying a cigarette) attributable to additive genetic, shared environmental, special twin environmental, and unique environmental factors.<br />Results: Additive genetic influences accounted for approximately half of the variance in smoking initiation in both African-American and European-American women. In the African-American subsample, the remaining variance was attributable primarily to unique environmental factors (46%; 95% CI: 28-71%). In the European-American subsample, only 12% (95% CI: 8-16%) of the variance was attributable to unique environmental factors, with the remainder accounted for by shared environmental (13%; 95% CI: 0-41%) and special twin environmental (24%; 95% CI: 0-52%) factors.<br />Conclusions: The estimated heritability of smoking initiation is substantial and nearly identical for African-American and European-American women, but the type of environmental factors that contribute to risk differ by race/ethnicity. Whereas the primary environmental influences on European-American women's smoking initiation are at the family level, those that impact African-American women's smoking initiation are primarily individual-specific.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adolescent
Behavior, Addictive genetics
Behavior, Addictive psychology
Family Health
Female
Humans
Missouri epidemiology
Prevalence
Risk
Smoking psychology
Twins genetics
Twins psychology
United States
Young Adult
Black or African American genetics
Black or African American psychology
Environment
Smoking epidemiology
Smoking genetics
White People genetics
White People psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0046
- Volume :
- 157
- Database :
- MEDLINE
- Journal :
- Drug and alcohol dependence
- Publication Type :
- Academic Journal
- Accession number :
- 26482091
- Full Text :
- https://doi.org/10.1016/j.drugalcdep.2015.10.002