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Broad-band UVB versus paint PUVA for palmoplantar psoriasis treatment.
- Source :
-
The Journal of dermatological treatment [J Dermatolog Treat] 2016; Vol. 27 (3), pp. 221-3. Date of Electronic Publication: 2015 Oct 20. - Publication Year :
- 2016
-
Abstract
- Background: Plaque-type palmoplantar psoriasis (PPTP) is a chronic recalcitrant dermatosis with treatment modalities ranging through topical, phototherapy or systemic. Phototherapy options include various forms of ultraviolet B (UVB) and ultraviolet A with prior psoralen sensitization (PUVA). Currently, few comparative studies have been reported.<br />Purpose: To compare Broad-Band UVB (BB-UVB) versus paint PUVA (p-PUVA) in regard to efficacy and safety in the treatment of PPTP.<br />Methods: A retrospective non-randomized cohort study comprised of all the patients with PPTP treated in our phototherapy centre during 2010-2012, either with BB-UVB or p-PUVA.<br />Results: Among the 248 patients included in this study, 122 received BB-UVB and 126 followed p-PUVA treatment. About 36 (30%) and 53 (42%) had complete remission, 29 (24%) and 59 (47%) responded partially and 57 (47%) and 14 (11%) patients did not improve with BB-UVB and p-PUVA, respectively. The odds ratio for remission (p-PUVA: BB-UVB) was 7.9. Duration of remission was 21.9 ± 1.34 months for p-PUVA and 16.75 ± 1.83 months for BB-UVB.<br />Conclusion: Both BB-UVB and p-PUVA are good therapeutic options for PPTP. P-PUVA emerges as the superior treatment modality, yielding a better and more extended response. BB-UVB represents a feasible alternative in patients with milder disease or possible contraindications for p-PUVA.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Foot Dermatoses drug therapy
Foot Dermatoses physiopathology
Foot Dermatoses radiotherapy
Hand Dermatoses drug therapy
Hand Dermatoses physiopathology
Hand Dermatoses radiotherapy
Humans
Male
Middle Aged
Psoriasis drug therapy
Psoriasis physiopathology
Psoriasis radiotherapy
Retrospective Studies
Treatment Outcome
Ultraviolet Rays
Foot Dermatoses therapy
Hand Dermatoses therapy
PUVA Therapy methods
Psoriasis therapy
Ultraviolet Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1471-1753
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of dermatological treatment
- Publication Type :
- Academic Journal
- Accession number :
- 26481287
- Full Text :
- https://doi.org/10.3109/09546634.2015.1093588