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Broad-band UVB versus paint PUVA for palmoplantar psoriasis treatment.

Authors :
Lozinski A
Barzilai A
Pavlotsky F
Source :
The Journal of dermatological treatment [J Dermatolog Treat] 2016; Vol. 27 (3), pp. 221-3. Date of Electronic Publication: 2015 Oct 20.
Publication Year :
2016

Abstract

Background: Plaque-type palmoplantar psoriasis (PPTP) is a chronic recalcitrant dermatosis with treatment modalities ranging through topical, phototherapy or systemic. Phototherapy options include various forms of ultraviolet B (UVB) and ultraviolet A with prior psoralen sensitization (PUVA). Currently, few comparative studies have been reported.<br />Purpose: To compare Broad-Band UVB (BB-UVB) versus paint PUVA (p-PUVA) in regard to efficacy and safety in the treatment of PPTP.<br />Methods: A retrospective non-randomized cohort study comprised of all the patients with PPTP treated in our phototherapy centre during 2010-2012, either with BB-UVB or p-PUVA.<br />Results: Among the 248 patients included in this study, 122 received BB-UVB and 126 followed p-PUVA treatment. About 36 (30%) and 53 (42%) had complete remission, 29 (24%) and 59 (47%) responded partially and 57 (47%) and 14 (11%) patients did not improve with BB-UVB and p-PUVA, respectively. The odds ratio for remission (p-PUVA: BB-UVB) was 7.9. Duration of remission was 21.9 ± 1.34 months for p-PUVA and 16.75 ± 1.83 months for BB-UVB.<br />Conclusion: Both BB-UVB and p-PUVA are good therapeutic options for PPTP. P-PUVA emerges as the superior treatment modality, yielding a better and more extended response. BB-UVB represents a feasible alternative in patients with milder disease or possible contraindications for p-PUVA.

Details

Language :
English
ISSN :
1471-1753
Volume :
27
Issue :
3
Database :
MEDLINE
Journal :
The Journal of dermatological treatment
Publication Type :
Academic Journal
Accession number :
26481287
Full Text :
https://doi.org/10.3109/09546634.2015.1093588