Divergent Reactivity of Rhodium(I) Carbenes Derived from Indole Annulations.

Authors :: Li X
Li H
Song W
Tseng PS
Liu L
Guzei IA
Tang W
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 Oct 26; Vol. 54 (44), pp. 12905-8. Date of Electronic Publication: 2015 Sep 07.
Publication Year :: 2015
Abstract: Rhodium(I) carbenes were generated from propargylic alcohol derivatives as the result of a dehydrative indole annulation. Depending on the choice of the electron-withdrawing group on the aniline nitrogen nucleophile, either a cyclopropanation product or dimerization product was obtained chemoselectively. Intramolecular hydroamidation occurred for the same type of propargylic alcohol derivatives when other transition-metal catalysts were employed.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)