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Camellia sinensis Mediated Enhancement of Humoral Immunity to Particulate and Non-particulate Antigens.

Authors :
Khan A
Ali NH
Santercole V
Paglietti B
Rubino S
Kazmi SU
Farooqui A
Source :
Phytotherapy research : PTR [Phytother Res] 2016 Jan; Vol. 30 (1), pp. 41-8. Date of Electronic Publication: 2015 Oct 18.
Publication Year :
2016

Abstract

The most common drinking beverage in large portion of the world is Camellia sinensis (green tea). In the present study, we evaluated the adjuvant effect of green tea and tea polyphenols to particulate and non-particulate antigens. BALB/c mice were immunized with particulate and non-particulate antigens. Modulation of immunoglobulin-secreting splenocytes, IgG-mediated and IgM-mediated immunity, was evaluated by hemolytic plaque assay and enzyme-linked immunosorbent assay, respectively. Dose-dependent response of tea polyphenols was also assayed. Phenolic content was measured in crude preparations of green tea. We observed a stimulatory effect of green tea preparations on humoral immune response mediated by the increased number of antibody-secreted cells in spleen. A significant increase in IgM-mediated and IgG-mediated immune response to non-particulate antigen was also observed in green tea-treated animals. A dose-dependent adjuvant effect was seen in the case of tea polyphenols for a longer period of time compared with crude tea preparations. This study indicates polyphenols as major constituents responsible for the enhanced and sustained adjuvant activity of green tea. We suggest that tea polyphenols might be considered for real-life evaluation during adjuvant-mediated vaccination trial programs.<br /> (Copyright © 2015 John Wiley & Sons, Ltd.)

Details

Language :
English
ISSN :
1099-1573
Volume :
30
Issue :
1
Database :
MEDLINE
Journal :
Phytotherapy research : PTR
Publication Type :
Academic Journal
Accession number :
26478000
Full Text :
https://doi.org/10.1002/ptr.5498