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Effect of steroidal anti-inflammatory drugs on Escherichia coli endotoxin-induced mastitis in the cow.
- Source :
-
Journal of dairy science [J Dairy Sci] 1989 Jan; Vol. 72 (1), pp. 241-9. - Publication Year :
- 1989
-
Abstract
- Effects of intramammary infusion of prednisolone (40 mg) or intramuscular injection of dexamethasone (30 mg) or flumethasone (5 mg) on local and systemic signs in Escherichia coli endotoxin-induced mastitis were studied. The effect of varying intervals (0, 2, and 4 h) between intramammary infusion of endotoxin and prednisolone in the same quarter was determined. Intramammary infusion of endotoxin (.01 mg lipopolysaccharide of E. coli) produced inflammation of the infused quarter, fever, tachycardia, and leukopenia followed by a neutrophilic leukocytosis in the blood and a decrease in plasma zinc and iron concentrations. All corticosteroid treatments, except intramammary administration of prednisolone 4 h after endotoxin infusion, enhanced leukocytosis and diminished local signs of inflammation. Intramuscular injection of dexamethasone or flumethasone together with intramammary infusion of endotoxin and intramammary administration of prednisolone 2 h after lipopolysaccharide infusion completely abolished the febrile response. Abolishment of fever and attenuation of several hematologic and blood biochemical changes may be explained by diminished synthesis of endogenous mediators within the inflamed quarters due to glucocorticosteroid action.
- Subjects :
- Animals
Cattle
Dexamethasone administration & dosage
Dexamethasone therapeutic use
Escherichia coli Infections blood
Escherichia coli Infections drug therapy
Female
Flumethasone administration & dosage
Flumethasone therapeutic use
Glucocorticoids administration & dosage
Injections, Intramuscular
Iron blood
Mastitis, Bovine blood
Mastitis, Bovine chemically induced
Mastitis, Bovine microbiology
Prednisolone administration & dosage
Prednisolone therapeutic use
Zinc blood
Endotoxins toxicity
Escherichia coli Infections veterinary
Glucocorticoids therapeutic use
Mastitis, Bovine drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0022-0302
- Volume :
- 72
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of dairy science
- Publication Type :
- Academic Journal
- Accession number :
- 2647798
- Full Text :
- https://doi.org/10.3168/jds.S0022-0302(89)79102-5