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Impact of pulmonary fibrosis and elevated pulmonary pressures on right ventricular function in patients with systemic sclerosis.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2016 Mar; Vol. 55 (3), pp. 504-12. Date of Electronic Publication: 2015 Oct 15. - Publication Year :
- 2016
-
Abstract
- Objectives: Right ventricular (RV) dysfunction is of great prognostic value in patients with SSc. The aim of the present study was to assess in these patients the relationship between pulmonary fibrosis and elevated pulmonary pressure (PHT) with RV function.<br />Methods: A total of 102 SSc patients who underwent thoracic CT and transthoracic echocardiography were included. Speckle tracking-derived RV free wall strain was used to assess RV function.<br />Results: A total of 51 (50%) SSc patients did not have pulmonary fibrosis or PHT, 32 (31%) patients had pulmonary fibrosis but no PHT and the remaining 19 (19%) patients had both pulmonary fibrosis and PHT. Patients with both pulmonary fibrosis and PHT had the most impaired RV free wall strain [-16.8% (s.d. 3.1)] compared with patients with pulmonary fibrosis and no PHT [-21.5% (s.d. 3.6)] and patients with no pulmonary fibrosis and no PHT [-24.0% (s.d. 4.4)]. All three SSc groups showed impaired RV free wall strain compared with controls [-28.0% (s.d. 4.2)]. Importantly, multivariate regression analysis demonstrated that pulmonary fibrosis and left ventricular ejection fraction were independently associated with impaired RV free wall strain in SSc patients.<br />Conclusion: SSc patients show impaired RV function compared with controls. Both pulmonary fibrosis and PHT are independently associated with RV dysfunction.<br /> (© The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Adult
Age Factors
Aged
Analysis of Variance
Case-Control Studies
Echocardiography methods
Female
Humans
Hypertension, Pulmonary diagnosis
Linear Models
Male
Middle Aged
Multivariate Analysis
Pulmonary Fibrosis diagnostic imaging
Retrospective Studies
Risk Assessment
Scleroderma, Systemic diagnosis
Severity of Illness Index
Sex Factors
Tomography, X-Ray Computed methods
Ventricular Dysfunction, Right physiopathology
Hypertension, Pulmonary complications
Image Interpretation, Computer-Assisted
Pulmonary Fibrosis complications
Scleroderma, Systemic complications
Ventricular Dysfunction, Right diagnostic imaging
Ventricular Dysfunction, Right etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0332
- Volume :
- 55
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 26472568
- Full Text :
- https://doi.org/10.1093/rheumatology/kev342