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Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling.
Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling.
- Source :
-
Nanotoxicology [Nanotoxicology] 2016; Vol. 10 (4), pp. 445-52. Date of Electronic Publication: 2015 Oct 15. - Publication Year :
- 2016
-
Abstract
- Copper oxide nanoparticles (CuONPs), metal oxide nanoparticles were used in multiple applications including wood preservation, antimicrobial textiles, catalysts for carbon monoxide oxidation and heat transfer fluid in machines. We investigated the effects of CuONPs on the respiratory system in Balb/c mice. In addition, to investigate the effects of CuONPs on asthma development, we used a murine model of ovalbumin (OVA)-induced asthma. CuONPs markedly increased airway hyper-responsiveness (AHR), inflammatory cell counts, proinflammatory cytokines and reactive oxygen species (ROS). CuONPs induced airway inflammation and mucus secretion with increases in phosphorylation of the MAPKs (Erk, JNK and p38). In the OVA-induced asthma model, CuONPs aggravated the increased AHR, inflammatory cell count, proinflammatory cytokines, ROS and immunoglobulin E induced by OVA exposure. In addition, CuONPs markedly increased inflammatory cell infiltration into the lung and mucus secretions, and MAPK phosphorylation was elevated compared to OVA-induced asthmatic mice. Taken together, CuONPs exhibited toxicity on the respiratory system, which was associated with the MAPK phosphorylation. In addition, CuONPs exposure aggravated the development of asthma. We conclude that CuONPs exposure has a potential toxicity in humans with respiratory disease.
- Subjects :
- Animals
Asthma chemically induced
Asthma pathology
Bronchoalveolar Lavage Fluid
Cell Count
Copper chemistry
Cytokines metabolism
Disease Models, Animal
Female
Immunoglobulin E blood
Lung metabolism
Lung pathology
Matrix Metalloproteinase 9 metabolism
Mice
Mitogen-Activated Protein Kinases metabolism
Nanoparticles chemistry
Ovalbumin
Phosphorylation
Reactive Oxygen Species metabolism
Respiratory Hypersensitivity chemically induced
Asthma metabolism
Copper toxicity
Inflammation chemically induced
MAP Kinase Signaling System drug effects
Mucus metabolism
Nanoparticles toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1743-5404
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nanotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 26472121
- Full Text :
- https://doi.org/10.3109/17435390.2015.1078851