Back to Search
Start Over
Eradication Rates of Helicobacter pylori in Korea Over the Past 10 years and Correlation of the Amount of Antibiotics Use: Nationwide Survey.
- Source :
-
Helicobacter [Helicobacter] 2016 Aug; Vol. 21 (4), pp. 266-78. Date of Electronic Publication: 2015 Oct 16. - Publication Year :
- 2016
-
Abstract
- Background: The efficacy of proton-pump inhibitor-amoxicillin-clarithromycin therapy for H. pylori eradication has decreased over time.<br />Objective: We assessed the trend of H. pylori eradication rates over the last 10 years and the relationship between the eradication rates and the amount of macrolide antibiotic use in a country with a high prevalence of H. pylori infection.<br />Methods: This vast nationwide multicenter study was conducted with 34,139 adults treated for H. pylori infection from January 2001 to December 2010. The defined daily dose per km(2) (DSD) of macrolide antibiotics was calculated (n = 141,019) using the Health Insurance Review & Assessment data base from 2008 to 2010 in the two cities which had the lowest (Jeju city) or highest (Chuncheon city) eradication rate.<br />Results: The eradication rates of proton-pump inhibitor-amoxicillin-clarithromycin therapy ranged 84.9-87.5% from 2001 to 2007, and those of 2008 to 2010 ranged 80.0-81.4% with a decreasing trend (p < 0.0001). The decreasing trend of eradication rates for the overall first-line therapy was observed only in three of the seven geographic areas in Korea (p < 0.0001). The DSD of macrolide antibiotics was significantly higher in Jeju than Cheunchon city (0.85 vs 0.52, p < 0.0001).<br />Conclusions: H. pylori eradication rates with clarithromycin-containing triple therapy in Korea showed a decreasing trend over the past 10 years, although the trend varied among geographic areas. This difference may be associated with the amount of macrolide antibiotic use.<br /> (© 2015 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Amoxicillin therapeutic use
Clarithromycin therapeutic use
Humans
Korea
Male
Middle Aged
Proton Pump Inhibitors therapeutic use
Spatio-Temporal Analysis
Surveys and Questionnaires
Treatment Failure
Young Adult
Anti-Bacterial Agents therapeutic use
Drug Utilization
Helicobacter Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1523-5378
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Helicobacter
- Publication Type :
- Academic Journal
- Accession number :
- 26470999
- Full Text :
- https://doi.org/10.1111/hel.12279