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Sleep aspects on video-polysomnography in LRRK2 mutation carriers.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2015 Nov; Vol. 30 (13), pp. 1839-43. Date of Electronic Publication: 2015 Oct 15. - Publication Year :
- 2015
-
Abstract
- Background: Rapid eye movement sleep behavior disorder and sleepiness precede or accompany idiopathic Parkinson's disease (PD), but their presence in subjects with leucine-rich repeat kinase 2 mutations is unknown.<br />Methods: Ten patients with leucine-rich repeat kinase 2-associated PD, four healthy leucine-rich repeat kinase 2 mutation carriers, 20 patients with idiopathic PD, and 12 healthy controls underwent clinical assessments and a nighttime video-polysomnography.<br />Results: No sleep changes, no rapid eye movement sleep behavior disorder, or rapid eye movement sleep without atonia was found in the 14 subjects with leucine-rich repeat kinase 2mutations compared with controls, whereas 41% of patients with idiopathic PD had rapid eye movement sleep behavior disorder. Eventually, 20% of patients with leucine-rich repeat kinase 2-associated PD had abnormal periodic leg movements, a frequency similar to the idiopathic PD group frequency.<br />Conclusions: The sleep phenotype in leucine-rich repeat kinase 2 mutations parallels that of idiopathic PD, except for absent rapid eye movement sleep behavior disorder here in the presymptomatic and symptomatic stages.<br /> (© 2015 International Parkinson and Movement Disorder Society.)
- Subjects :
- Adult
Aged
Electroencephalography
Female
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Male
Middle Aged
Parkinson Disease genetics
Video Recording
Mutation genetics
Parkinson Disease complications
Polysomnography
Protein Serine-Threonine Kinases genetics
REM Sleep Behavior Disorder diagnosis
REM Sleep Behavior Disorder etiology
REM Sleep Behavior Disorder genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 30
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 26468079
- Full Text :
- https://doi.org/10.1002/mds.26412