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Therapeutic effects of minocycline on mild-to-moderate depression in HIV patients: a double-blind, placebo-controlled, randomized trial.
- Source :
-
International clinical psychopharmacology [Int Clin Psychopharmacol] 2016 Jan; Vol. 31 (1), pp. 20-6. - Publication Year :
- 2016
-
Abstract
- Patients with the HIV infection are at high risk for developing depression. The aim of this study was to investigate the safety and efficacy of antidepressant effects of minocycline on HIV patients with depression. Forty-six HIV patients, with mild-to-moderate depression and a Hamilton Depression Rating Scale (HDRS) up to 18, participated in a parallel, randomized, double-blind, placebo-controlled trial and underwent 6 weeks of treatment with either minocycline (100 mg twice daily) or placebo in the same manner. Patients were assessed using HDRS at baseline and at weeks 3 and 6. The primary outcome measure was to evaluate the efficacy of minocycline in improving depressive symptoms. General linear model repeated measures showed significant effect for time × treatment interaction on the HDRS score during the trial course [F(2, 88)=7.50, P=0.001]. There was no significant difference between the two groups regarding adverse events. No serious adverse event was reported. The administration of 100 mg minocycline twice daily seems to be safe and effective in improving depressive symptoms in HIV/AIDS patients with mild-to-moderate depression.
- Subjects :
- Acquired Immunodeficiency Syndrome complications
Acquired Immunodeficiency Syndrome psychology
Adolescent
Adult
Anti-Bacterial Agents adverse effects
Antidepressive Agents adverse effects
Depression psychology
Double-Blind Method
Female
HIV Infections psychology
Humans
Linear Models
Male
Middle Aged
Minocycline adverse effects
Treatment Outcome
Young Adult
Anti-Bacterial Agents therapeutic use
Antidepressive Agents therapeutic use
Depression complications
Depression drug therapy
HIV Infections complications
Minocycline therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5857
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International clinical psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 26465919
- Full Text :
- https://doi.org/10.1097/YIC.0000000000000098