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Heat fractionation and thermotolerance: a review.
- Source :
-
Cancer research [Cancer Res] 1978 Jul; Vol. 38 (7), pp. 1843-51. - Publication Year :
- 1978
-
Abstract
- A rational approach to the design of clinical protocols combining fractionated hyperthermia plus X-irradiation or hyperthermia plus chemotherapy requires an understanding of the biology of fractionated heat alone. Mammalian cells growing in vitro can dramatically increase their tolerance to thermal damage (i.e., reduce the cellular inactivation rate) after prior heat conditioning. Although the mechanism(s) for this cellular thermotolerance is still unknown, it is apparent that the thermal history, the heat fractionation interval, and the recovery conditions all modify significantly the degree of thermotolerance subsequently exhibited. At the tissue level, the role of cellular thermotolerance is further complicated by host physiological mechanisms. Few data are available on heat fractionation in vivo, and the relative importance of physiological versus cellular effects remains to be defined.
- Subjects :
- Animals
Cell Cycle
Cell Division
Cells, Cultured
Chromatin metabolism
Hot Temperature
Humans
Hydrogen-Ion Concentration
Kinetics
Membrane Lipids metabolism
Neoplasms, Experimental therapy
Protein Biosynthesis
Skin pathology
Thermodynamics
Body Temperature Regulation
Hyperthermia, Induced methods
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 38
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 26462