Treatment Responsiveness in CIDP Patients with Diabetes Is Associated with Higher Degrees of Demyelination.

Authors :: Abraham A
Alabdali M
Qrimli M
Albulaihe H
Breiner A
Barnett C
Katzberg HD
Lovblom LE
Perkins BA
Bril V
Source :: PloS one [PLoS One] 2015 Oct 13; Vol. 10 (10), pp. e0139674. Date of Electronic Publication: 2015 Oct 13 (Print Publication: 2015).
Publication Year :: 2015
Abstract: Introduction: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is one of several chronic treatable acquired demyelinating neuropathies.<br />Objectives: To explore the association between the degree of demyelination in CIDP, and treatment responsiveness.<br />Methods: A retrospective chart review of CIDP subjects assessed between 1997 and 2013 was performed to compare treatment responsiveness using different sets of criteria.<br />Results: 99 CIDP patients were included, 34 with diabetes mellitus (DM). Treatment responsiveness was higher in CIDP-DM fulfilling 1 or more EFNS/PNS criteria, (63% vs. 31%, p = 0.03), and in CIDP+DM fulfilling 2 or more criteria (89% vs. 36%, p = 0.01). Nonetheless, treatment responsiveness in CIDP+DM had the highest odds ratio (3.73, p = 0.01). Similar results were also shown in simplified uniform study criteria, with 10% cut off values for CIDP-DM, compared to 30% for CIDP+DM.<br />Conclusion: In CIDP+DM, higher degrees of demyelination are associated with treatment responsiveness, implying the need to adjust current criteria in these patients.

Subjects :: Humans
ROC Curve
Societies, Medical
Treatment Outcome
Diabetes Mellitus therapy
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating complications
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating therapy

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