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Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2015 Oct 28; Vol. 63 (42), pp. 9295-305. Date of Electronic Publication: 2015 Oct 19. - Publication Year :
- 2015
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Abstract
- The lipid peroxidation of unsaturated fatty acids (UFAs) in the retina not only threatens visual cells but also affects the physiological health of the retina. In this work, the potential damages caused by daily visible light exposure on retinal UFAs were evaluated via a simulated in vitro model. At the same time, the benefits of dietary supplementation of blueberries to the eyes were also assessed. After prolonged light exposure, lipid peroxidation occurred for both docosahexaenoic and arachidonic acids (DHA and AA, respectively). The oxidized UFAs presented obvious cytotoxicity and significantly inhibited cell growth in retinal pigment epithelium cells. Among the different blueberry polyphenol fractions, the flavonoid-rich fraction, in which quercetin was discovered as the main component, was considerably better in preventing visible light-induced DHA lipid peroxidation than the anthocyanin- and phenolic acid-rich fractions. Then the retinal protective activity of blueberry polyphenols against light-induced retinal injury was confirmed in vivo. On the basis of the above results, inhibiting lipid peroxidation of UFAs in the retina is proposed to be another important function mechanism for antioxidants to nourish eyes.
- Subjects :
- Animals
Dietary Supplements analysis
Humans
Lipid Peroxidation drug effects
Lipid Peroxidation radiation effects
Rabbits
Retina drug effects
Retina metabolism
Retina radiation effects
Retinal Diseases etiology
Retinal Diseases metabolism
Blueberry Plants chemistry
Fatty Acids, Unsaturated metabolism
Light adverse effects
Plant Extracts administration & dosage
Polyphenols administration & dosage
Retinal Diseases drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 63
- Issue :
- 42
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26456696
- Full Text :
- https://doi.org/10.1021/acs.jafc.5b04341