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Caffeine treatment prevents rapid eye movement sleep deprivation-induced impairment of late-phase long-term potentiation in the dentate gyrus.
- Source :
-
The European journal of neuroscience [Eur J Neurosci] 2015 Nov; Vol. 42 (10), pp. 2843-50. - Publication Year :
- 2015
-
Abstract
- The CA1 and dentate gyrus (DG) are physically and functionally closely related areas of the hippocampus, but they differ in various respects, including their reactions to different insults. The purpose of this study was to determine the protective effects of chronic caffeine treatment on late-phase long-term potentiation (L-LTP) and its signalling cascade in the DG area of the hippocampus of rapid eye movement sleep-deprived rats. Rats were chronically treated with caffeine (300 mg/L drinking water) for 4 weeks, after which they were sleep-deprived for 24 h. L-LTP was induced in in anaesthetized rats, and extracellular field potentials from the DG area were recorded in vivo. The levels of L-LTP-related signalling proteins were assessed by western blot analysis. Sleep deprivation markedly reduced L-LTP magnitude, and basal levels of total cAMP response element-binding protein (CREB), phosphorylated CREB (P-CREB), and calcium/calmodulin kinase IV (CaMKIV). Chronic caffeine treatment prevented the reductions in the basal levels of P-CREB, total CREB and CaMKIV in sleep-deprived rats. Furthermore, caffeine prevented post-L-LTP sleep deprivation-induced downregulation of P-CREB and brain-derived neurotrophic factor in the DG. The current findings show that caffeine treatment prevents acute sleep deprivation-induced deficits in brain function.<br /> (© 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
- Subjects :
- Animals
Brain Waves drug effects
Brain-Derived Neurotrophic Factor metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 4 metabolism
Cyclic AMP Response Element-Binding Protein metabolism
Dentate Gyrus metabolism
Excitatory Postsynaptic Potentials drug effects
Male
Phosphorylation
Rats
Rats, Wistar
Signal Transduction drug effects
Sleep Deprivation metabolism
Caffeine administration & dosage
Dentate Gyrus drug effects
Dentate Gyrus physiopathology
Long-Term Potentiation drug effects
Sleep Deprivation physiopathology
Sleep, REM
Subjects
Details
- Language :
- English
- ISSN :
- 1460-9568
- Volume :
- 42
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The European journal of neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 26449851
- Full Text :
- https://doi.org/10.1111/ejn.13092