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Vaccination with a Porcine Reproductive and Respiratory Syndrome (PRRS) Modified Live Virus Vaccine Followed by Challenge with PRRS Virus and Porcine Circovirus Type 2 (PCV2) Protects against PRRS but Enhances PCV2 Replication and Pathogenesis Compared to Results for Nonvaccinated Cochallenged Controls.
- Source :
-
Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2015 Dec; Vol. 22 (12), pp. 1244-54. Date of Electronic Publication: 2015 Oct 07. - Publication Year :
- 2015
-
Abstract
- Coinfections involving porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) contribute to a group of disease syndromes known as porcine circovirus-associated disease (PCVAD). Presumably, PRRSV infection enhances PCV2 replication as a result of modulation of host immunity. The purpose of this study was to evaluate PCV2 replication and pathogenesis in pigs vaccinated with a PRRS modified live virus (MLV) vaccine and subsequently challenged with a combination of PRRSV and PCV2. During the early postchallenge period, the number of pigs with PRRSV-associated clinical signs was decreased, and average daily gain (ADG) was increased, in the vaccinated group, demonstrating the protective effect of PRRS vaccination. However, during the later postchallenge period, more pigs in the vaccinated group showed increased PCV2 viremia, decreased ADG, increased PCVAD clinical signs, and increased mortality. In this disease model, the early benefits of PRRSV vaccination were outweighed by the later amplification of PCVAD.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
- Subjects :
- Animals
Antibodies, Viral blood
Circoviridae Infections immunology
Circoviridae Infections prevention & control
Circovirus immunology
Coinfection veterinary
Coinfection virology
Disease Models, Animal
Porcine Reproductive and Respiratory Syndrome immunology
Porcine Reproductive and Respiratory Syndrome virology
Porcine respiratory and reproductive syndrome virus genetics
Sus scrofa
Swine
Swine Diseases immunology
Vaccines, Attenuated administration & dosage
Vaccines, Attenuated immunology
Viral Vaccines administration & dosage
Viremia prevention & control
Viremia veterinary
Virus Replication
Circoviridae Infections veterinary
Circovirus physiology
Porcine Reproductive and Respiratory Syndrome prevention & control
Porcine respiratory and reproductive syndrome virus immunology
Swine Diseases prevention & control
Swine Diseases virology
Viral Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1556-679X
- Volume :
- 22
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Clinical and vaccine immunology : CVI
- Publication Type :
- Academic Journal
- Accession number :
- 26446422
- Full Text :
- https://doi.org/10.1128/CVI.00434-15