PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapment on Polytetrafluoroethylene Surface for Application in Periodontal Diseases.

Authors :: Nardo T
Chiono V
Ciardelli G
Tabrizian M
Source :: Macromolecular bioscience [Macromol Biosci] 2016 Feb; Vol. 16 (2), pp. 288-98. Date of Electronic Publication: 2015 Oct 07.
Publication Year :: 2016
Abstract: Inert polytetrafluoroethylene (PTFE) membranes for periodontal regeneration suffer from weak osteoconductive properties. In this work, a strategy for hydroxyapatite (HAp) coating on PTFE films through an adhesive layer of self-polymerized 3,4-dihydroxy-DL-phenylalanine (polyDOPA) was developed to improve surface properties. Physico-chemical and morphological analysis demonstrated the deposition of polyDOPA and HAp, with an increase in surface roughness and wettability. A discontinuous coating was present after 14 days in PBS and MC3T3-E1 cells proliferation and adhesion were improved. Results confirmed the potential application of polyDOPA/HAp-coated films for periodontal disease treatments.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Cell Line
Mice
Periodontal Diseases metabolism
Periodontal Diseases therapy
Coated Materials, Biocompatible chemistry
Coated Materials, Biocompatible pharmacology
Durapatite chemistry
Durapatite pharmacology
Indoles chemistry
Indoles pharmacology
Materials Testing
Membranes, Artificial
Polymers chemistry
Polymers pharmacology
Polytetrafluoroethylene chemistry
Polytetrafluoroethylene pharmacology

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