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Multiple Genetic Mutations Associated with Polymyxin Resistance in Acinetobacter baumannii.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Dec; Vol. 59 (12), pp. 7899-902. Date of Electronic Publication: 2015 Oct 05. - Publication Year :
- 2015
-
Abstract
- We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were significant differences in terms of antibiotic susceptibility and genetic determinants of resistance in A. baumannii isolates that had developed polymyxin B resistance in vivo compared to isolates that had developed polymyxin B resistance in vitro.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
- Subjects :
- Acinetobacter Infections drug therapy
Acinetobacter Infections microbiology
Acinetobacter baumannii enzymology
Acinetobacter baumannii isolation & purification
Acyltransferases metabolism
Bacterial Proteins metabolism
Drug Resistance, Multiple, Bacterial genetics
Gene Expression
Humans
Isoenzymes genetics
Isoenzymes metabolism
Microbial Sensitivity Tests
Molecular Sequence Annotation
Mutation
Transcription Factors metabolism
beta-Lactams pharmacology
Acinetobacter baumannii drug effects
Acinetobacter baumannii genetics
Acyltransferases genetics
Anti-Bacterial Agents pharmacology
Bacterial Proteins genetics
Polymyxin B pharmacology
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 59
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 26438500
- Full Text :
- https://doi.org/10.1128/AAC.01884-15