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Microglia: Dynamic Mediators of Synapse Development and Plasticity.
- Source :
-
Trends in immunology [Trends Immunol] 2015 Oct; Vol. 36 (10), pp. 605-613. - Publication Year :
- 2015
-
Abstract
- Neuronal communication underlies all brain activity and the genesis of complex behavior. Emerging research has revealed an unexpected role for immune molecules in the development and plasticity of neuronal synapses. Moreover microglia, the resident immune cells of the brain, express and secrete immune-related signaling molecules that alter synaptic transmission and plasticity in the absence of inflammation. When inflammation does occur, microglia modify synaptic connections and synaptic plasticity required for learning and memory. Here we review recent findings demonstrating how the dynamic interactions between neurons and microglia shape the circuitry of the nervous system in the healthy brain and how altered neuron-microglia signaling could contribute to disease.<br /> (Copyright © 2015. Published by Elsevier Ltd.)
- Subjects :
- Aging genetics
Aging immunology
Aging metabolism
Animals
Brain physiology
Central Nervous System immunology
Central Nervous System metabolism
Humans
Inflammation genetics
Inflammation immunology
Inflammation metabolism
Neuroimmunomodulation
Neuronal Plasticity
Signal Transduction
Synapses physiology
Microglia physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4981
- Volume :
- 36
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Trends in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26431938
- Full Text :
- https://doi.org/10.1016/j.it.2015.08.008