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CD25 expression on residual leukemic blasts at the time of allogeneic hematopoietic stem cell transplant predicts relapse in patients with acute myeloid leukemia without complete remission.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2016; Vol. 57 (6), pp. 1375-81. Date of Electronic Publication: 2015 Dec 23. - Publication Year :
- 2016
-
Abstract
- Recent studies have shown that CD25 expression at the time of diagnosis of acute myeloid leukemia (AML) may be associated with an unfavorable outcome. We focus on patients with AML without complete remission (CR) and examine the clinical correlation between surface CD25 expression at the time of transplant and subsequent transplant outcomes. We observed a significant difference in overall survival (OS), disease-free survival (DFS) and cumulative incidence of relapse (CIR) between CD25 positive (+) (n = 22) and negative (-) groups (n = 44) (2-year OS; CD25 (+) group: 5% vs. CD25 (-) group: 40%, p < 0.0001, 2-year DFS; 5% vs. 29%, p < 0.0001, 2-year CIR; 77% vs. 52%, p = 0.03). Multivariate analysis showed that CD25 expression was an independent adverse factor for OS (p = 0.002) and relapse (p = 0.001). Patients with AML with residual CD25 positive blasts at the time of transplant may require additional therapy before or after transplant to improve survival.
- Subjects :
- Adult
Aged
Cause of Death
Female
Flow Cytometry
Gene Expression
Graft vs Host Disease etiology
Graft vs Host Disease prevention & control
Hematopoietic Stem Cell Transplantation
Humans
Immunophenotyping
Interleukin-2 Receptor alpha Subunit genetics
Leukemia, Myeloid, Acute mortality
Leukemia, Myeloid, Acute therapy
Male
Middle Aged
Prognosis
Recurrence
Remission Induction
Retrospective Studies
Risk Factors
Transplantation Conditioning
Transplantation, Homologous
Biomarkers, Tumor
Interleukin-2 Receptor alpha Subunit metabolism
Leukemia, Myeloid, Acute diagnosis
Leukemia, Myeloid, Acute metabolism
Neoplasm, Residual diagnosis
Neoplasm, Residual metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 57
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 26422713
- Full Text :
- https://doi.org/10.3109/10428194.2015.1099644