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Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues.
- Source :
-
Genomics [Genomics] 2015 Dec; Vol. 106 (6), pp. 373-83. Date of Electronic Publication: 2015 Sep 28. - Publication Year :
- 2015
-
Abstract
- Chlamydia pneumoniae is an obligate intracellular bacterium implicated in a wide range of human diseases including atherosclerosis and Alzheimer's disease. Efforts to understand the relationships between C. pneumoniae detected in these diseases have been hindered by the availability of sequence data for non-respiratory strains. In this study, we sequenced the whole genomes for C. pneumoniae isolates from atherosclerosis and Alzheimer's disease, and compared these to previously published C. pneumoniae genomes. Phylogenetic analyses of these new C. pneumoniae strains indicate two sub-groups within human C. pneumoniae, and suggest that both recombination and mutation events have driven the evolution of human C. pneumoniae. Further fine-detailed analyses of these new C. pneumoniae sequences show several genetically variable loci. This suggests that similar strains of C. pneumoniae are found in the brain, lungs and cardiovascular system and that only minor genetic differences may contribute to the adaptation of particular strains in human disease.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Adaptation, Physiological genetics
Alzheimer Disease microbiology
Atherosclerosis microbiology
Brain microbiology
Chlamydophila Infections microbiology
Chlamydophila pneumoniae classification
Chlamydophila pneumoniae physiology
Evolution, Molecular
Heart microbiology
Host-Pathogen Interactions
Humans
Mutation
Phylogeny
Polymorphism, Single Nucleotide
Recombination, Genetic
Respiratory System microbiology
Species Specificity
Chlamydophila pneumoniae genetics
Genome, Bacterial genetics
Genomics methods
Sequence Analysis, DNA methods
Subjects
Details
- Language :
- English
- ISSN :
- 1089-8646
- Volume :
- 106
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 26420648
- Full Text :
- https://doi.org/10.1016/j.ygeno.2015.09.008