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Conformational Memory of a Protein Revealed by Single-Molecule Spectroscopy.
- Source :
-
The journal of physical chemistry. B [J Phys Chem B] 2015 Nov 05; Vol. 119 (44), pp. 13964-70. Date of Electronic Publication: 2015 Oct 14. - Publication Year :
- 2015
-
Abstract
- Proteins are supramolecular machines that carry out a wide range of different functions, many of which require flexibility. Up until now spontaneous conformational fluctuations of proteins have always been assumed to reflect a stochastic random process. However, if changing between different conformational states was random, then it would be difficult to understand how conformational control of protein function could have evolved. Here we demonstrate that a single protein can show conformational memory. This is exactly the process that can facilitate the evolution of control of switching between two conformational states that can then be used to regulate protein function.
Details
- Language :
- English
- ISSN :
- 1520-5207
- Volume :
- 119
- Issue :
- 44
- Database :
- MEDLINE
- Journal :
- The journal of physical chemistry. B
- Publication Type :
- Academic Journal
- Accession number :
- 26420643
- Full Text :
- https://doi.org/10.1021/acs.jpcb.5b07494