Mesostructured TiO2 Gated Periodic Mesoporous Organosilica-Based Nanotablets for Multistimuli-responsive Drug Release.

Authors :: Wang T
Guan B
Wang X
Li X
Zhang Y
Qiao ZA
Liu Y
Huo Q
Source :: Small (Weinheim an der Bergstrasse, Germany) [Small] 2015 Nov 25; Vol. 11 (44), pp. 5907-11. Date of Electronic Publication: 2015 Sep 29.
Publication Year :: 2015
Abstract: A multistimuli-responsive drug carrier is designed and successfully synthesized by self-assembly of thiol-modified periodic mesoporous organosilica (PMO) nanoparticles, coated gold nanoparticles (AuNPs), and mesostructured titanium dioxide (TiO2). Dye-loaded PMO-Au@TiO2 nanotablets are shown to respond to environmental changes (pH, temperature, and light) to achieve controlled release.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Erythrocytes drug effects
Hemolysis drug effects
Humans
Methylene Blue pharmacology
Nanoparticles ultrastructure
Nitrogen chemistry
Porosity
Temperature
Drug Liberation
Nanoparticles chemistry
Organosilicon Compounds chemistry
Silicon Dioxide chemistry
Titanium chemistry

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