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Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury.
- Source :
-
Journal of neurotrauma [J Neurotrauma] 2016 Jun 15; Vol. 33 (12), pp. 1103-14. Date of Electronic Publication: 2015 Nov 13. - Publication Year :
- 2016
-
Abstract
- Bone marrow stromal cells (BMSCs) have been reported to exert potential neuroprotective properties in models of neurotrauma, although precise mechanisms underlying their benefits are poorly understood. Despite this lack of knowledge, several clinical trials have been initiated using these cells. To determine whether local mechanisms mediate BMSC neuroprotective actions, we grafted allogeneic BMSCs to sites of severe, compressive spinal cord injury (SCI) in Sprague-Dawley rats. Cells were administered 48 h after the original injury. Additional animals received allogeneic MSCs that were genetically modified to secrete brain-derived neurotrophic factor (BDNF) to further determine whether a locally administered neurotrophic factor provides or extends neuroprotection. When assessed 2 months post-injury in a clinically relevant model of severe SCI, BMSC grafts with or without BDNF secretion failed to improve motor outcomes. Thus, allogeneic grafts of BMSCs do not appear to act through local mechanisms, and future clinical trials that acutely deliver BMSCs to actual sites of injury within days are unlikely to be beneficial. Additional studies should address whether systemic administration of BMSCs alter outcomes from neurotrauma.
- Subjects :
- Animals
Behavior, Animal physiology
Disease Models, Animal
Female
Rats
Rats, Sprague-Dawley
Bone Marrow Transplantation methods
Brain-Derived Neurotrophic Factor metabolism
Motor Activity physiology
Spinal Cord Injuries physiopathology
Spinal Cord Injuries surgery
Stromal Cells transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1557-9042
- Volume :
- 33
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of neurotrauma
- Publication Type :
- Academic Journal
- Accession number :
- 26414795
- Full Text :
- https://doi.org/10.1089/neu.2015.4009