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Association of Visceral Fat and Liver Fat With Hyperuricemia.
- Source :
-
Arthritis care & research [Arthritis Care Res (Hoboken)] 2016 Apr; Vol. 68 (4), pp. 553-61. - Publication Year :
- 2016
-
Abstract
- Objective: To examine cross-sectionally whether intraabdominal fat area (IAFA), i.e., visceral fat, and liver fat assessed by computed tomography (CT) are independently associated with hyperuricemia.<br />Methods: Subjects were 801 Japanese men not taking antidiabetic, antihypertensive, or urate-lowering medications, without any history of renal disease, cardiovascular disease, or cancer, and with serum creatinine <1.5 mg/dl. Abdominal, thoracic, and thigh fat areas were measured by CT. Total fat area (TFA) was the sum of these fat areas. Total subcutaneous fat area (TSFA) was TFA minus IAFA. Liver fat was assessed by liver-to-spleen (L/S) ratio measured by CT. Hyperuricemia was defined as serum uric acid level >7.0 mg/dl. Its association with adiposity was tested using logistic regression.<br />Results: The prevalence of hyperuricemia was 19.6% (157 men). Both greater IAFA and lower L/S ratio were independently associated with hyperuricemia in models that simultaneously included IAFA and L/S ratio: multiple-adjusted odds ratios of hyperuricemia for quintiles 3, 4, and 5 of IAFA were 2.16 (95% confidence interval [95% CI] 1.02-4.59), 2.41 (95% CI 1.13-5.16), and 4.00 (95% CI 1.81-8.85), respectively, compared to quintile 1, and the L/S ratios for quintiles 3, 2, and 1 were 2.34 (95% CI 1.16-4.75), 2.15 (95% CI 1.06-4.34), and 2.79 (95% CI 1.35-5.76), respectively, compared to quintile 5. Both IAFA and L/S ratio remained significant even after adjusting for abdominal subcutaneous fat area, TFA, TSFA, body mass index, or waist circumference. Of all fat measurements, IAFA had the strongest association with hyperuricemia by Akaike's information criteria.<br />Conclusion: Greater amounts of both visceral fat and liver fat were independently associated with hyperuricemia.<br /> (© 2016, American College of Rheumatology.)
- Subjects :
- Adult
Aged
Biomarkers blood
Chi-Square Distribution
Cross-Sectional Studies
Humans
Hyperuricemia blood
Hyperuricemia diagnosis
Hyperuricemia physiopathology
Intra-Abdominal Fat diagnostic imaging
Japan epidemiology
Liver diagnostic imaging
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prevalence
Prospective Studies
Risk Factors
Tomography, X-Ray Computed
Uric Acid blood
Adiposity
Hyperuricemia epidemiology
Intra-Abdominal Fat physiopathology
Liver physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2151-4658
- Volume :
- 68
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Arthritis care & research
- Publication Type :
- Academic Journal
- Accession number :
- 26414410
- Full Text :
- https://doi.org/10.1002/acr.22729