Re-examination of genetic and nutritional factors related to trichothecene biosynthesis in Fusarium graminearum.

Authors :: Kitou Y
Nakajima Y
Maeda K
Jin Q
Nishiuchi T
Kanamaru K
Kobayashi T
Kimura M
Source :: Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2016; Vol. 80 (2), pp. 414-7. Date of Electronic Publication: 2015 Sep 28.
Publication Year :: 2016
Abstract: Disruption of two Fusarium genes that negatively regulate trichothecene biosynthesis was reported to cause a drastic increase in trichothecene production. However, careful inspection of these genes revealed that neither was significantly related to trichothecene production. Agmatine medium maintained the expression of trichothecene genes at significant levels, resulting in a 2-3-fold increase in the final yield, as compared to glutamine medium.

Subjects :: Agmatine metabolism
Agmatine pharmacology
Culture Media pharmacology
Fungal Proteins metabolism
Fusarium drug effects
Fusarium metabolism
Gene Deletion
Glutamine metabolism
Glutamine pharmacology
Transcription Factors metabolism
Transcription, Genetic
Trichothecenes genetics
Fungal Proteins genetics
Fusarium genetics
Gene Expression Regulation, Fungal
Transcription Factors genetics
Trichothecenes biosynthesis

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