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[The study of the association of polymorphism rs659366 gene UCP2 c obesity and type 2 diabetes among residents of the Moscow Region].
- Source :
-
Voprosy pitaniia [Vopr Pitan] 2015; Vol. 84 (1), pp. 44-9. - Publication Year :
- 2015
-
Abstract
- 1112 people from Moscow region have been surveyed. Genotyping of rs659366 polymorphism UCP2 gene was performed using allele-specific amplification, result detection in real time and using TaqMan-probes complementary DNA polymorphic sites. The study of rs659366 polymorphism of the UCP2 gene has showed that 36.9% of patients had genotype AA, 46.7%--genotype AG, and 16.5%--genotype GG. The frequency of allele A was 60.2%, allele G--39.8%. BMI, value of fat mass, visceral fat area, serum glucose and triglyceride levels were significantly higher in carriers of A allele in the homozygous and heterozygous state than in carriers of G allele in the homozygous state. Frequency of A allele compared with G allele in obese patients (BMI greater than 30 kg/m2) was: OR--1.52; CI (1.24-1.86), p = 0.001, and in diabetes mellitus type 2--OR--1.22; CI (0.910-1.622), p = 0.19.
- Subjects :
- Diabetes Mellitus, Type 2 epidemiology
Female
Gene Frequency
Heterozygote
Homozygote
Humans
Male
Moscow epidemiology
Obesity epidemiology
Sex Factors
Uncoupling Protein 2
Diabetes Mellitus, Type 2 genetics
Ion Channels genetics
Mitochondrial Proteins genetics
Obesity genetics
Polymorphism, Genetic
Subjects
Details
- Language :
- Russian
- ISSN :
- 0042-8833
- Volume :
- 84
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Voprosy pitaniia
- Publication Type :
- Academic Journal
- Accession number :
- 26402942