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Enhancing the pharmacokinetic/pharmacodynamic properties of therapeutic nucleotides using lipid nanoparticle systems.
- Source :
-
Future medicinal chemistry [Future Med Chem] 2015; Vol. 7 (13), pp. 1751-69. Date of Electronic Publication: 2015 Sep 24. - Publication Year :
- 2015
-
Abstract
- Although activity has been reported in vivo, free nucleic acid-based drugs are rapidly degraded and cleared following systemic administration. To address these challenges and improve the potency and bioavailability of genetic drugs, significant efforts have been made to develop effective delivery systems of which lipid nanoparticles (LNP) represent the most advanced technology currently available. In this review, we will describe and discuss the improvements to the pharmacokinetic and pharmacodynamic properties of nucleic acid-based drugs mediated by LNP delivery. It is envisioned that the significant improvements in potency and safety, largely driven by the development of LNP encapsulated siRNA drugs, will be translatable to other types of genetic drugs and enable the rapid development of potent molecular tools and drugs.
- Subjects :
- Animals
DNA, Catalytic administration & dosage
DNA, Catalytic pharmacokinetics
DNA, Catalytic pharmacology
Drug Compounding methods
Drug Delivery Systems
Humans
MicroRNAs administration & dosage
MicroRNAs pharmacokinetics
MicroRNAs pharmacology
Nucleotides pharmacology
RNA, Catalytic administration & dosage
RNA, Catalytic pharmacokinetics
RNA, Catalytic pharmacology
RNA, Small Interfering administration & dosage
RNA, Small Interfering pharmacokinetics
RNA, Small Interfering pharmacology
Drug Carriers chemistry
Lipids chemistry
Nanoparticles chemistry
Nucleotides administration & dosage
Nucleotides pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1756-8927
- Volume :
- 7
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Future medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26399560
- Full Text :
- https://doi.org/10.4155/fmc.15.108