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Non-invasive Measurement of Skin Autofluorescence as a Beneficial Surrogate Marker for Atherosclerosis in Patients with Type 2 Diabetes.
- Source :
-
The journal of medical investigation : JMI [J Med Invest] 2015; Vol. 62 (3-4), pp. 126-9. - Publication Year :
- 2015
-
Abstract
- Advanced glycation end-products (AGEs) are thought to play a major role in the pathogenesis of diabetic vascular complications. Skin autofluorescence (AF) was recently reported to represent tissue AGEs accumulation with a non-invasive method. The aim of the present study was to evaluate association between AF value and diabetic vascular complications, such as retinopathy, nephropathy and cervical atherosclerosis using the carotid intima-media thickness (IMT), an established marker of cardiovascular disease in patients with type 2 diabetes. A total of 68 patients with type 2 diabetes were enrolled in a cross-sectional manner. AGEs accumulation was measured with AF reader. Clinical parameters were collected at the time of AF and IMT measurement. Max-IMT was correlated with age and AF (r=0.407, p=0.001), but not with HbA1c, GA, and pentosidine. Also, AF was not correlated with HbA1c, GA and pentosidine, but was correlated with age (r=0.560, p<0.001), duration of diabetes (r=0.256, p<0.05). Multivariate regression analysis revealed that AF, but not age, was an independent determinant of max-IMT. In conclusion, AF might be a beneficial surrogate marker for evaluating carotid atherosclerosis in patients with type 2 diabetes non-invasively. J. Med. Invest. 62: 126-129, August, 2015.
- Subjects :
- Aged
Atherosclerosis etiology
Biomarkers
Carotid Intima-Media Thickness
Cross-Sectional Studies
Female
Fluorescence
Humans
Male
Middle Aged
Atherosclerosis diagnosis
Carotid Artery Diseases diagnosis
Diabetes Mellitus, Type 2 complications
Diabetic Angiopathies diagnosis
Glycation End Products, Advanced metabolism
Skin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1349-6867
- Volume :
- 62
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- The journal of medical investigation : JMI
- Publication Type :
- Academic Journal
- Accession number :
- 26399335
- Full Text :
- https://doi.org/10.2152/jmi.62.126