Back to Search
Start Over
Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors.
- Source :
-
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2015; Vol. 34 (11), pp. 763-85. Date of Electronic Publication: 2015 Sep 23. - Publication Year :
- 2015
-
Abstract
- Ribose modified 1'-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbrüggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramidate prodrugs were tested for their anti-HCV activity.
- Subjects :
- Chemistry Techniques, Synthetic
Enzyme Inhibitors chemistry
Pyrimidine Nucleosides chemistry
DNA-Directed RNA Polymerases antagonists & inhibitors
Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors pharmacology
Hepacivirus enzymology
Pyrimidine Nucleosides chemical synthesis
Pyrimidine Nucleosides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2335
- Volume :
- 34
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Nucleosides, nucleotides & nucleic acids
- Publication Type :
- Academic Journal
- Accession number :
- 26398773
- Full Text :
- https://doi.org/10.1080/15257770.2015.1075550