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IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis.
- Source :
-
International journal of oncology [Int J Oncol] 2015 Nov; Vol. 47 (5), pp. 1971-80. Date of Electronic Publication: 2015 Sep 14. - Publication Year :
- 2015
-
Abstract
- The inhibitor of nuclear factor kappa B zeta (IκBζ) is an atypical member of the IκB protein family. Its function in regulating the activity of the transcription factor nuclear factor kappa B (NFκB) as well as its involvement in cancer-associated processes is poorly understood. In glioma patients, enhanced expression of IκBζ in tumor specimen is associated with poor prognosis. Here we report that IκBζ is upregulated in a glioma cell line resistant towards NFκB-dependent non-apoptotic cell death. Upon γ-irradiation of glioma cells, IκBζ expression is enhanced, and subsequently serves as a transcriptional activator of the tumor promoting cytokines interleukin (IL-6), IL-8 and chemokine (C-X-C motif) ligand 1 (CXCL1) that are known to be involved in glioma associated inflammatory processes. In contrast, shRNA-mediated knockdown of IκBζ reduces the expression of the aforementioned cytokines. We propose a previously unappreciated role of IκBζ in the inflammatory micromilieu as well as progression in glioma.
- Subjects :
- Adaptor Proteins, Signal Transducing
Cell Death radiation effects
Cell Line, Tumor
Chemokine CXCL1 biosynthesis
Gamma Rays
Gene Expression Regulation, Neoplastic radiation effects
Humans
I-kappa B Proteins antagonists & inhibitors
I-kappa B Proteins genetics
Interleukin-6 biosynthesis
Interleukin-8 biosynthesis
NF-kappa B biosynthesis
Nuclear Proteins antagonists & inhibitors
Nuclear Proteins genetics
Prognosis
RNA, Small Interfering
Carcinogenesis genetics
Glioma genetics
I-kappa B Proteins biosynthesis
NF-kappa B genetics
Nuclear Proteins biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1791-2423
- Volume :
- 47
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of oncology
- Publication Type :
- Academic Journal
- Accession number :
- 26398661
- Full Text :
- https://doi.org/10.3892/ijo.2015.3159