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Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.
- Source :
-
PloS one [PLoS One] 2015 Sep 23; Vol. 10 (9), pp. e0138652. Date of Electronic Publication: 2015 Sep 23 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Background/aim: Recent genome-wide association studies have identified several loci influencing lipid levels. The present study focused on the triglycerides (TG)-associated locus, the APOA4-APOA5-ZNF259-BUD13 gene cluster on chromosome 11, to explore the role of genetic variants in this gene cluster in the development of increasing TG levels and coronary heart disease (CHD).<br />Methodology/principal Findings: Six single nucleotide polymorphisms (SNPs), rs4417316, rs651821, rs6589566, rs7396835, rs964184 and rs17119975, in the APOA4-APOA5-ZNF259-BUD13 gene cluster were selected and genotyped in 5374 healthy Chinese subjects. There were strong significant associations between the six SNPs and TG levels (P < 1.0 × 10(-8)). Moreover, a weighted genotype score was found to be associated with TG levels (P = 3.28 × 10(-13)). The frequencies of three common haplotypes were observed to be significantly different between the high TG group and the low TG group (P < 0.05). However, no significant effects were found for the SNPs regarding susceptibility to CHD in the Chinese case-control populations.<br />Conclusions/significance: This study highlights the genotypes, genotype scores and haplotypes of the APOA4-APOA5-ZNF259-BUD13 gene cluster that were associated with TG levels in a Chinese population; however, the genetic variants in this gene cluster did not increase the risk of CHD in the Chinese population.
- Subjects :
- Adult
Aged
Alleles
Apolipoprotein A-V
Asian People
China
Coronary Artery Disease pathology
Female
Genome-Wide Association Study
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Male
Membrane Transport Proteins
Middle Aged
Multigene Family
Risk Factors
Apolipoproteins A genetics
Carrier Proteins genetics
Coronary Artery Disease genetics
Polymorphism, Single Nucleotide
RNA-Binding Proteins genetics
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 10
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 26397108
- Full Text :
- https://doi.org/10.1371/journal.pone.0138652