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Role of Semen on Vaginal HIV-1 Transmission and Maraviroc Protection.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Dec; Vol. 59 (12), pp. 7847-51. Date of Electronic Publication: 2015 Sep 21. - Publication Year :
- 2015
-
Abstract
- We used bone marrow/liver/thymus (BLT) humanized mice to establish the effect of semen on vaginal HIV infection and on the efficacy of topically applied maraviroc. Our results demonstrate that vaginal transmission of cell-free HIV occurs efficiently in the presence of semen and that topically applied maraviroc efficiently prevents HIV transmission in the presence of semen. We also show that semen has no significant effect on the transmission of transmitted/founder viruses or cell-associated viruses.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
- Subjects :
- Administration, Intravaginal
Animals
CD4-Positive T-Lymphocytes drug effects
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes virology
Disease Models, Animal
Female
HIV Infections immunology
HIV Infections transmission
HIV Infections virology
HIV-1 physiology
Humans
Male
Maraviroc
Mice
Mice, Transgenic
Semen virology
Vagina immunology
Vagina virology
Viral Load drug effects
Anti-HIV Agents pharmacology
Cyclohexanes pharmacology
HIV Infections prevention & control
HIV-1 drug effects
Semen drug effects
Triazoles pharmacology
Vagina drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 59
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 26392489
- Full Text :
- https://doi.org/10.1128/AAC.01496-15