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Targeted PRINT Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation.
- Source :
-
Nano letters [Nano Lett] 2015 Oct 14; Vol. 15 (10), pp. 6371-8. Date of Electronic Publication: 2015 Sep 30. - Publication Year :
- 2015
-
Abstract
- In this Letter, we varied targeting ligand density of an EGFR binding affibody on the surface of two different hydrogel PRINT nanoparticles (80 nm × 320 and 55 nm × 60 nm) and monitored effects on target-cell association, off-target phagocytic uptake, biodistribution, and tumor accumulation. Interestingly, variations in ligand density only significantly altered in vitro internalization rates for the 80 nm × 320 nm particle. However, in vivo, both particle sizes experienced significant changes in biodistribution and pharmacokinetics as a function of ligand density. Overall, nanoparticle size and passive accumulation were the dominant factors eliciting tumor sequestration.
Details
- Language :
- English
- ISSN :
- 1530-6992
- Volume :
- 15
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nano letters
- Publication Type :
- Academic Journal
- Accession number :
- 26389971
- Full Text :
- https://doi.org/10.1021/acs.nanolett.5b01362