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Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice.
- Source :
-
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2016 Mar; Vol. 71 (3), pp. 290-9. Date of Electronic Publication: 2015 Sep 18. - Publication Year :
- 2016
-
Abstract
- In the present study, the possibility that a diabetic (DM) status might worsen age-related bone deterioration was explored in mice. Male CD-1 mice aged 2 (young control group) or 16 months, nondiabetic or made diabetic by streptozotocin injections, were used. DM induced a decrease in bone volume, trabecular number, and eroded surface, and in mineral apposition and bone formation rates, but an increased trabecular separation, in L1-L3 vertebrae of aged mice. Three-point bending and reference point indentation tests showed slight changes pointing to increased frailty and brittleness in the mouse tibia of diabetic old mice. DM was related to a decreased expression of both vascular endothelial growth factor and its receptor 2, which paralleled that of femoral vasculature, and increased expression of the pro-adipogenic gene peroxisome proliferator-activated receptor γ and adipocyte number, without affecting β-catenin pathway in old mouse bone. Concomitant DM in old mice failed to affect total glutathione levels or activity of main anti-oxidative stress enzymes, although xanthine oxidase was slightly increased, in the bone marrow, but increased the senescence marker caveolin-1 gene. In conclusion, DM worsens bone alterations of aged mice, related to decreased bone turnover and bone vasculature and increased senescence, independently of the anti-oxidative stress machinery.<br /> (© The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Animals
Bone Remodeling
Diabetes Mellitus, Experimental complications
Diabetes Mellitus, Experimental pathology
Lumbar Vertebrae diagnostic imaging
Lumbar Vertebrae metabolism
Lumbar Vertebrae pathology
Male
Mice
Osteoporosis diagnosis
Osteoporosis etiology
Tomography, X-Ray Computed
Aging
Bone Density
Diabetes Mellitus, Experimental metabolism
Osteogenesis physiology
Osteoporosis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1758-535X
- Volume :
- 71
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The journals of gerontology. Series A, Biological sciences and medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 26386012
- Full Text :
- https://doi.org/10.1093/gerona/glv160