Back to Search
Start Over
TYPE 2 (SUBRETINAL) NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION ASSOCIATED WITH PURE RETICULAR PSEUDODRUSEN PHENOTYPE.
- Source :
-
Retina (Philadelphia, Pa.) [Retina] 2016 Mar; Vol. 36 (3), pp. 449-57. - Publication Year :
- 2016
-
Abstract
- Purpose: To report the association of pure type 2 neovascularization (NV) in age-related macular degeneration occurring almost exclusively in patients with reticular pseudodrusen.<br />Methods: An observational retrospective cohort study of all eyes receiving antivascular endothelial growth factor therapy for newly diagnosed neovascular age-related macular degeneration by a single practitioner over a 6-year period. Only patients with treatment-naive, pure type 2 NV who also had either pre-neovascular imaging of the study eye or imaging of a nonneovascular fellow eye available to determine baseline characteristics including drusen type and choroidal thickness were incuded.<br />Results: Of 694 patients treated for neovascular age-related macular degeneration, only 8 met the inclusion criteria with pure type 2 NV. Of these, 7 (88%) had exclusively reticular pseudodrusen (5 in the nonneovascular fellow eye, 2 in the study eye before developing NV). Six (75%) patients in the affected neovascular eye and 6 (75%) in the fellow nonneovascular eye had choroidal thickness <120 μm. Mean follow-up was 46 months (range, 3.0-63.3). Best-corrected vision improved from 20/89 (range, 20/30-20/796) at baseline to 20/60 (range, 20/20-20/399) at last follow-up.<br />Conclusion: Pure type 2 NV is rare in age-related macular degeneration, occurring almost exclusively in patients with reticular pseudodrusen and thin choroids.
- Subjects :
- Aged
Aged, 80 and over
Angiogenesis Inhibitors therapeutic use
Bevacizumab therapeutic use
Cohort Studies
Extracellular Space
Female
Humans
Intravitreal Injections
Macular Degeneration diagnosis
Macular Degeneration drug therapy
Male
Optical Imaging
Phenotype
Ranibizumab therapeutic use
Receptors, Vascular Endothelial Growth Factor therapeutic use
Recombinant Fusion Proteins therapeutic use
Retinal Drusen diagnosis
Retinal Drusen drug therapy
Retinal Neovascularization diagnosis
Retinal Neovascularization drug therapy
Retrospective Studies
Tomography, Optical Coherence
Vascular Endothelial Growth Factor A antagonists & inhibitors
Visual Acuity physiology
Macular Degeneration complications
Retinal Drusen complications
Retinal Neovascularization etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1539-2864
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Retina (Philadelphia, Pa.)
- Publication Type :
- Academic Journal
- Accession number :
- 26383711
- Full Text :
- https://doi.org/10.1097/IAE.0000000000000758