Back to Search
Start Over
Sexual side-effects of antidepressant and antipsychotic drugs.
- Source :
-
Current opinion in psychiatry [Curr Opin Psychiatry] 2015 Nov; Vol. 28 (6), pp. 418-23. - Publication Year :
- 2015
-
Abstract
- Purpose of Review: Psychotropic-related sexual dysfunction is a quite frequent issue in clinical practice, mainly in chronic treatments affecting both quality of life and compliance.<br />Recent Findings: In the last decade fortunately antidepressants and antipsychotic compounds have been deeply screened in order to identify sexual adverse events that were commonly underdiagnosed and previously underestimated by clinicians and perhaps by pharmaceutical companies as well. Some differences in the mechanism of action are the nucleus of this poorly tolerated adverse event. All antidepressants with serotonergic activity can cause mild to severe sexual dysfunction such as decreased libido and delayed orgasm frequently (>60%) or anorgasmia and arousal difficulties sometimes (30%). In contrast, noradrenergic, dopaminergic, or melatonergic antidepressants do not cause sexual dysfunction but perhaps the clinical profile of patients receiving these compounds could be different. Antipsychotics that highly increase prolactin levels and strongly block dopamine receptors could be related to sexual dysfunction as well. Unfortunately, these dysfunctions are present during the long term after the antipsychotic onset to provide continued symptom control and enable recovery. Young patients suffering psychosis and concomitant sexual dysfunction (erectile and/or orgasmic difficulties) tend to show poor compliance in chronic treatments affecting the outcomes.<br />Summary: The implications of psychotropic-related sexual dysfunction in clinical practice are relevant mainly in patients under long-term treatment with previous satisfactory sexual life. Implications for future research about sexual dysfunction in all new treatments should be strongly taken into account.
- Subjects :
- Antidepressive Agents administration & dosage
Antidepressive Agents pharmacology
Antipsychotic Agents administration & dosage
Antipsychotic Agents pharmacology
Erectile Dysfunction chemically induced
Female
Humans
Male
Medication Adherence
Psychotic Disorders drug therapy
Psychotic Disorders metabolism
Psychotropic Drugs adverse effects
Quality of Life
Receptors, Dopamine drug effects
Receptors, Serotonin drug effects
Sexual Behavior drug effects
Antidepressive Agents adverse effects
Antipsychotic Agents adverse effects
Libido drug effects
Orgasm drug effects
Sexual Dysfunctions, Psychological chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1473-6578
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current opinion in psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 26382168
- Full Text :
- https://doi.org/10.1097/YCO.0000000000000198