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Diagnosis and Assessment of NAFLD: Definitions and Histopathological Classification.
- Source :
-
Seminars in liver disease [Semin Liver Dis] 2015 Aug; Vol. 35 (3), pp. 207-20. Date of Electronic Publication: 2015 Sep 17. - Publication Year :
- 2015
-
Abstract
- Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of clinical and histopathological changes including "simple" steatosis, steatosis with inflammation, steatohepatitis, cirrhosis, and hepatocellular carcinoma. It was initially described in the context of drug-induced liver injury and acute liver disease following jejunoileal bypass surgery, but since the early 1980s it has been widely acknowledged as the hepatic manifestation of metabolic syndrome. It now represents a burgeoning public health crisis and is fast becoming the main indication for liver transplantation in some parts of the world. Its true incidence and prevalence are unknown, although estimates have been made from large imaging studies. Liver biopsy interpretation is still regarded as the gold standard for making accurate diagnoses in NAFLD, but sampling limitations are recognized. Furthermore, clear definitions for key histopathological components have been lacking, resulting in significant interobserver variations in making a diagnosis of steatohepatitis. In this review the authors consider some aspects of classification and variant forms of NAFLD such as that occurring in children. They provide an update on grading and staging systems and histopathological prognostic factors, and address the role of liver biopsy in contemporary clinical care of patients with NAFLD.<br /> (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
- Subjects :
- Animals
Biopsy
Comorbidity
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Non-alcoholic Fatty Liver Disease epidemiology
Non-alcoholic Fatty Liver Disease history
Observer Variation
Predictive Value of Tests
Prognosis
Reproducibility of Results
Risk Factors
Severity of Illness Index
Liver pathology
Non-alcoholic Fatty Liver Disease classification
Non-alcoholic Fatty Liver Disease pathology
Terminology as Topic
Subjects
Details
- Language :
- English
- ISSN :
- 1098-8971
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Seminars in liver disease
- Publication Type :
- Academic Journal
- Accession number :
- 26378639
- Full Text :
- https://doi.org/10.1055/s-0035-1562942