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Early Life Antibiotic Exposure Is Not Associated with Growth in Young Children of Vellore, India.
- Source :
-
The Journal of pediatrics [J Pediatr] 2015 Nov; Vol. 167 (5), pp. 1096-102.e3. Date of Electronic Publication: 2015 Sep 12. - Publication Year :
- 2015
-
Abstract
- Objectives: To estimate the effects of antibiotic exposures in the first 6 months of life on short- and long-term growth.<br />Study Design: In a prospective observational cohort study of 497 children from Vellore, India, we estimated short-term effects of antibiotics during the first 6 months using longitudinal general linear regression to model weight-for-age, height-for-age, and weight-for-height z-scores in monthly intervals. To estimate long-term effects, we modeled growth from 6 months to 3 years as a function of antibiotic use in the first 6 months. We also estimated the effects of antibiotics on the monthly relative risks of underweight, stunting, and wasting in the first 6 months and to 3 years.<br />Results: Underweight, stunting, and wasting were common in this population: 31%, 32%, and 15% on average after 6 months of age, respectively. There was no association between antibiotic exposures before 6 months and growth during that period. From 6 months to 3 years, adjusted absolute differences in weight and height were small (approximately -100 g and no more than -2 mm overall, respectively) and not statistically significant.<br />Conclusions: Antibiotic exposures early in life were not associated with increased or decreased growth. The combination of malnutrition and recurrent illness likely complicate the relationship between antibiotic exposures and growth among children in low and middle-income countries.<br />Competing Interests: The other authors declare no conflicts of interest.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Child, Preschool
Cryptosporidiosis physiopathology
Female
Follow-Up Studies
Growth Disorders etiology
Humans
Incidence
India epidemiology
Infant
Infant, Newborn
Male
Prospective Studies
Risk Factors
Time Factors
Anti-Bacterial Agents therapeutic use
Body Height physiology
Body Weight physiology
Cryptosporidiosis drug therapy
Growth Disorders epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6833
- Volume :
- 167
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 26372535
- Full Text :
- https://doi.org/10.1016/j.jpeds.2015.08.015