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Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC2-signaling deficient mice.
- Source :
-
Scientific reports [Sci Rep] 2015 Sep 15; Vol. 5, pp. 14044. Date of Electronic Publication: 2015 Sep 15. - Publication Year :
- 2015
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Abstract
- Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and use intercellular signaling to synchronize their timekeeping activities so that the SCN can coordinate brain physiology and behavior. The neuropeptide vasoactive intestinal polypeptide (VIP) and its VPAC2 receptor form a key component of intercellular signaling systems in the SCN and critically control cellular coupling. Targeted mutations in either the intracellular clock or intercellular neuropeptide signaling mechanisms, such as VIP-VPAC2 signaling, can lead to desynchronization of SCN neuronal clocks and loss of behavioral rhythms. An important goal in chronobiology is to develop interventions to correct deficiencies in circadian timekeeping. Here we show that extended exposure to constant light promotes synchrony among SCN clock cells and the expression of ~24 h rhythms in behavior in mice in which intercellular signaling is disrupted through loss of VIP-VPAC2 signaling. This study highlights the importance of SCN synchrony for the expression of rhythms in behavior and reveals how non-invasive manipulations in the external environment can be used to overcome neurochemical communication deficits in this important brain system.
- Subjects :
- Animals
Behavior, Animal
Mice
Mice, Knockout
Neurons metabolism
Neurons radiation effects
Physical Exertion genetics
Physical Exertion radiation effects
Receptors, Vasoactive Intestinal Peptide, Type II deficiency
Suprachiasmatic Nucleus metabolism
Suprachiasmatic Nucleus radiation effects
Circadian Clocks genetics
Circadian Clocks radiation effects
Circadian Rhythm genetics
Circadian Rhythm radiation effects
Light
Receptors, Vasoactive Intestinal Peptide, Type II genetics
Receptors, Vasoactive Intestinal Peptide, Type II metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 26370467
- Full Text :
- https://doi.org/10.1038/srep14044