Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors.

Authors :: Khattab SN
Khalil HH
Bekhit AA
El-Rahman MM
El-Faham A
Albericio F
Source :: Molecules (Basel, Switzerland) [Molecules] 2015 Sep 02; Vol. 20 (9), pp. 15976-88. Date of Electronic Publication: 2015 Sep 02.
Publication Year :: 2015
Abstract: Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity.

Subjects :: Clorgyline pharmacology
Monoamine Oxidase Inhibitors chemistry
Monoamine Oxidase Inhibitors pharmacology
Morpholines chemistry
Piperidines chemistry
Quantitative Structure-Activity Relationship
Amino Acids chemistry
Monoamine Oxidase Inhibitors chemical synthesis
Triazines chemistry

Full Text Access

Tools