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Increased albumin quotient (QAlb) in patients after first clinical event suggestive of multiple sclerosis is associated with development of brain atrophy and greater disability 48 months later.
- Source :
-
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2016 May; Vol. 22 (6), pp. 770-81. Date of Electronic Publication: 2015 Sep 11. - Publication Year :
- 2016
-
Abstract
- Background: The utility of blood-brain barrier (BBB) biomarkers for clinical and magnetic resonance imaging progression in multiple sclerosis (MS) has not been extensively investigated.<br />Objectives: To determine whether cerebrospinal fluid (CSF) measures of BBB at clinical onset predict radiological and clinical deterioration over 48 months.<br />Methods: This longitudinal study included 182 patients after first clinical event suggestive of MS treated with weekly intramuscular interferon beta-1a. CSF and serum samples were analyzed for leukocytes, total protein, albumin, immunoglobulins, and oligoclonal bands. Optimal thresholds for the albumin quotient (QAlb) were determined. Mixed-effect model analyses, adjusted for age, gender, and treatment escalation, were used to analyze relationship between CSF measures and disease activity outcomes over 48 months of follow-up.<br />Results: Increased QAlb at clinical onset was associated with enlargement of lateral ventricles (p = .001) and greater whole brain (p = .003), white matter (p < .001), corpus callosum (p < .001), and thalamus (p = .003) volume loss over 48 months. Higher QAlb was associated with higher Expanded Disability Status Scale score over 48 months (p = .002).<br />Conclusions: Increased QAlb at clinical onset is associated with increased brain atrophy and greater disability in patients after first clinical event suggestive of MS.<br /> (© The Author(s), 2015.)
- Subjects :
- Adult
Atrophy pathology
Biomarkers
Brain diagnostic imaging
Female
Follow-Up Studies
Humans
Male
Multiple Sclerosis blood
Serum Albumin
Young Adult
Albumins cerebrospinal fluid
Blood-Brain Barrier
Brain pathology
Disease Progression
Multiple Sclerosis cerebrospinal fluid
Multiple Sclerosis physiopathology
Severity of Illness Index
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0970
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Publication Type :
- Academic Journal
- Accession number :
- 26362893
- Full Text :
- https://doi.org/10.1177/1352458515601903