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An analysis of the blood pressure and safety outcomes to renal denervation in African Americans and Non-African Americans in the SYMPLICITY HTN-3 trial.
- Source :
-
Journal of the American Society of Hypertension : JASH [J Am Soc Hypertens] 2015 Oct; Vol. 9 (10), pp. 769-779. Date of Electronic Publication: 2015 Aug 08. - Publication Year :
- 2015
-
Abstract
- SYMPLICITY HTN-3, the first trial of renal denervation (RDN) versus sham, enrolled 26% African Americans, a prospectively stratified cohort. Although the 6-month systolic blood pressure (SBP) reduction in African Americans (AAs) was similar in the RDN group (-15.5 ± 25.4 mm Hg, n = 85 vs. -17.8 ± 29.2, n = 49, P = .641), the sham SBP response was 9.2 mm Hg greater (P = .057) in AAs than non-AAs. In multivariate analyses, sham SBP response was predicted by an interaction between AA and a complex antihypertensive regimen (at least one antihypertensive medication prescribed ≥3 times daily), while in the RDN group, SBP response was predicted by an interaction between AA race and baseline BP ≥ 180 mm Hg. AA race did not independently predict SBP response in either sham or RDN. There appears to be effect modification by race with individual-level patient characteristics in both treatment arms that affect the observed pattern of SBP responses.<br /> (Copyright © 2015 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Black or African American
Aged
Antihypertensive Agents therapeutic use
Blood Pressure Monitoring, Ambulatory
Catheter Ablation
Cohort Studies
Female
Humans
Hypertension ethnology
Male
Medication Adherence
Middle Aged
Multivariate Analysis
Prospective Studies
Sympathectomy methods
Treatment Outcome
Hypertension physiopathology
Hypertension surgery
Kidney innervation
Sympathetic Nervous System surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1878-7436
- Volume :
- 9
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Hypertension : JASH
- Publication Type :
- Academic Journal
- Accession number :
- 26362830
- Full Text :
- https://doi.org/10.1016/j.jash.2015.08.001