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Validation of a T1 and T2* leakage correction method based on multiecho dynamic susceptibility contrast MRI using MION as a reference standard.
- Source :
-
Magnetic resonance in medicine [Magn Reson Med] 2016 Aug; Vol. 76 (2), pp. 613-25. Date of Electronic Publication: 2015 Sep 12. - Publication Year :
- 2016
-
Abstract
- Purpose: A combined biophysical- and pharmacokinetic-based method is proposed to separate, quantify, and correct for both T1 and T2* leakage effects using dual-echo dynamic susceptibility contrast (DSC) acquisitions to provide more accurate hemodynamic measures, as validated by a reference intravascular contrast agent (CA).<br />Theory and Methods: Dual-echo DSC-MRI data were acquired in two rodent glioma models. The T1 leakage effects were removed and also quantified to subsequently correct for the remaining T2* leakage effects. Pharmacokinetic, biophysical, and combined biophysical and pharmacokinetic models were used to obtain corrected cerebral blood volume (CBV) and cerebral blood flow (CBF), and these were compared with CBV and CBF from an intravascular CA.<br />Results: T1 -corrected CBV was significantly overestimated compared with MION CBV, while T1 + T2*-correction yielded CBV values closer to the reference values. The pharmacokinetic and simplified biophysical methods showed similar results and underestimated CBV in tumors exhibiting strong T2* leakage effects. The combined method was effective for correcting T1 and T2* leakage effects across tumor types.<br />Conclusion: Correcting for both T1 and T2* leakage effects yielded more accurate measures of CBV. The combined correction method yields more reliable CBV measures than either correction method alone, but for certain brain tumor types (e.g., gliomas), the simplified biophysical method may provide a robust and computationally efficient alternative. Magn Reson Med 76:613-625, 2016. © 2015 Wiley Periodicals, Inc.<br /> (© 2015 Wiley Periodicals, Inc.)
- Subjects :
- Animals
Cell Line, Tumor
Contrast Media
Image Interpretation, Computer-Assisted methods
Magnetic Resonance Imaging standards
Male
Rats
Rats, Inbred F344
Rats, Wistar
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Algorithms
Artifacts
Brain Neoplasms diagnostic imaging
Extravasation of Diagnostic and Therapeutic Materials diagnostic imaging
Glioma diagnostic imaging
Image Enhancement methods
Magnetic Resonance Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2594
- Volume :
- 76
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Magnetic resonance in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26362714
- Full Text :
- https://doi.org/10.1002/mrm.25906