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Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia.
- Source :
-
Neural plasticity [Neural Plast] 2015; Vol. 2015, pp. 375391. Date of Electronic Publication: 2015 Aug 18. - Publication Year :
- 2015
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Abstract
- Prophylactic subacute administration of zinc decreases lipoperoxidation and cell death following a transient cerebral hypoxia-ischemia, thus suggesting neuroprotective and preconditioning effects. Chemokines and growth factors are also involved in the neuroprotective effect in hypoxia-ischemia. We explored whether zinc prevents the cerebral cortex-hippocampus injury through regulation of CCL2, CCR2, FGF2, and IGF-1 expression following a 10 min of common carotid artery occlusion (CCAO). Male rats were grouped as follows: (1) Zn96h, rats injected with ZnCl2 (one dose every 24 h during four days); (2) Zn96h + CCAO, rats treated with ZnCl2 before CCAO; (3) CCAO, rats with CCAO only; (4) Sham group, rats with mock CCAO; and (5) untreated rats. The cerebral cortex-hippocampus was dissected at different times before and after CCAO. CCL2/CCR2, FGF2, and IGF-1 expression was assessed by RT-PCR and ELISA. Learning in Morris Water Maze was achieved by daily training during 5 days. Long-term memory was evaluated on day 7 after learning. Subacute administration of zinc increased expression of CCL2, CCR2, FGF2, and IGF-1 in the early and late phases of postreperfusion and prevented the CCAO-induced memory loss in the rat. These results might be explained by the induction of neural plasticity because of the expression of CCL2 and growth factors.
- Subjects :
- Animals
Carotid Stenosis psychology
Chemokine CCL2 biosynthesis
Fibroblast Growth Factor 2 biosynthesis
Insulin-Like Growth Factor I biosynthesis
Male
Maze Learning drug effects
Memory, Long-Term drug effects
Rats
Rats, Wistar
Receptors, CCR2 biosynthesis
Chlorides therapeutic use
Hypoxia-Ischemia, Brain drug therapy
Hypoxia-Ischemia, Brain psychology
Memory Disorders etiology
Memory Disorders prevention & control
Zinc Compounds therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1687-5443
- Volume :
- 2015
- Database :
- MEDLINE
- Journal :
- Neural plasticity
- Publication Type :
- Academic Journal
- Accession number :
- 26355725
- Full Text :
- https://doi.org/10.1155/2015/375391