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IgA vasculitis (formerly Henoch-Schönlein purpura) in an adult with systemic lupus erythematosus.
- Source :
-
BMJ case reports [BMJ Case Rep] 2015 Sep 09; Vol. 2015. Date of Electronic Publication: 2015 Sep 09. - Publication Year :
- 2015
-
Abstract
- We report a case of a 65-year-old man with systemic lupus erythematosus (SLE) and antiphospholipid syndrome, presenting palpable purpuric lesions, necrotic blisters and swelling ankles, after a previous tracheobronchitis episode. Laboratory data were remarkable for mild proteinuria and imaging studies were normal. A skin biopsy showed IgA deposits on superficial dermal capillaries and IgA vasculitis (IgAV) (former Henoch-Schönlein purpura) was assumed. The patient was treated with colchicine, deflazacort and azathioprine, but as a regression in the purpuric lesions was noted, a decline in renal function was detected. A kidney biopsy revealed mesangial proliferation with IgA deposition and IgAV nephritis was considered. Immunosuppressive treatment was adjusted, with progressive normalisation of renal function and disappearance of proteinuria over a monthly follow-up; after 6 months, total remission was achieved. To the best of our knowledge, this is the first reported case of IgAV in an adult patient with SLE.<br /> (2015 BMJ Publishing Group Ltd.)
- Subjects :
- Aged
Humans
IgA Vasculitis drug therapy
IgA Vasculitis immunology
IgA Vasculitis pathology
Lupus Erythematosus, Systemic drug therapy
Lupus Erythematosus, Systemic immunology
Male
Remission Induction
Antihypertensive Agents administration & dosage
IgA Vasculitis diagnosis
Immunosuppressive Agents administration & dosage
Lupus Erythematosus, Systemic pathology
Ramipril administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1757-790X
- Volume :
- 2015
- Database :
- MEDLINE
- Journal :
- BMJ case reports
- Publication Type :
- Academic Journal
- Accession number :
- 26354836
- Full Text :
- https://doi.org/10.1136/bcr-2015-210121