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Ribosomal DNA transcription in dorsal raphe nucleus neurons is increased in residual schizophrenia compared to depressed patients with affective disorders.
- Source :
-
Psychiatry research [Psychiatry Res] 2015 Dec 15; Vol. 230 (2), pp. 233-41. Date of Electronic Publication: 2015 Sep 01. - Publication Year :
- 2015
-
Abstract
- The central serotonergic system is implicated differentially in the pathogenesis of depression and schizophrenia. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in both disorders. The study was carried out on paraffin-embedded brains from 27 depressed (15 major depressive disorder, MDD and 12 bipolar disorder, BD) and 17 schizophrenia (9 residual and 8 paranoid) patients and 28 matched controls without mental disorders. The transcriptional activity of ribosomal DNA (rDNA) in DRN neurons was evaluated by the AgNOR silver staining method. A significant effect of diagnosis on rDNA activity was found in the cumulative analysis of all DRN subnuclei. Further analysis revealed an increase in this activity in residual (but not paranoid) schizophrenia compared to depressed (both MDD and BD) patients. The effect was most probably neither confounded by suicide nor related to antidepressant and antipsychotic medication. Our findings suggest that increased activity of rDNA in DRN neurons is a distinct phenomenon in residual schizophrenia, related presumably to differentially disturbed inputs to the DRN and/or their local transformation compared with depressive episodes in patients with affective disorders.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Bipolar Disorder diagnosis
Bipolar Disorder epidemiology
Cross-Sectional Studies
Depressive Disorder, Major diagnosis
Depressive Disorder, Major epidemiology
Dorsal Raphe Nucleus pathology
Female
Humans
Male
Middle Aged
Mood Disorders diagnosis
Mood Disorders epidemiology
Mood Disorders metabolism
Neurons metabolism
Neurons pathology
Schizophrenia diagnosis
Bipolar Disorder metabolism
DNA, Ribosomal biosynthesis
Depressive Disorder, Major metabolism
Dorsal Raphe Nucleus metabolism
Schizophrenia metabolism
Transcription, Genetic physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7123
- Volume :
- 230
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 26350704
- Full Text :
- https://doi.org/10.1016/j.psychres.2015.08.045