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Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats.
- Source :
-
AAPS PharmSciTech [AAPS PharmSciTech] 2016 Aug; Vol. 17 (4), pp. 834-43. Date of Electronic Publication: 2015 Sep 08. - Publication Year :
- 2016
-
Abstract
- In the current study, antidiabetic activity and toxic effects of zinc oxide nanoparticles (ZnO) were investigated in diabetic rats compared to zinc sulfate (ZnSO4) with particular emphasis on oxidative stress parameters. One hundred and twenty male Wistar rats were divided into two healthy and diabetic groups, randomly. Each major group was further subdivided into five subgroups and then orally supplemented with various doses of ZnO (1, 3, and 10 mg/kg) and ZnSO4 (30 mg/kg) for 56 consecutive days. ZnO showed greater antidiabetic activity compared to ZnSO4 evidenced by improved glucose disposal, insulin levels, and zinc status. The altered activities of erythrocyte antioxidant enzymes as well as raised levels of lipid peroxidation and a marked reduction of total antioxidant capacity were observed in rats receiving ZnO. ZnO nanoparticles acted as a potent antidiabetic agent, however, severely elicited oxidative stress particularly at higher doses.
- Subjects :
- Animals
Antioxidants metabolism
Diabetes Mellitus, Experimental chemically induced
Diabetes Mellitus, Experimental metabolism
Lipid Peroxidation drug effects
Male
Rats
Rats, Wistar
Streptozocin pharmacology
Diabetes Mellitus, Experimental drug therapy
Hypoglycemic Agents pharmacology
Nanoparticles administration & dosage
Oxidative Stress drug effects
Zinc Oxide pharmacology
Zinc Sulfate pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1530-9932
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- AAPS PharmSciTech
- Publication Type :
- Academic Journal
- Accession number :
- 26349687
- Full Text :
- https://doi.org/10.1208/s12249-015-0405-y