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Profile Analysis of Chemotherapy-induced Nausea and Vomiting in Patients Treated with Concomitant Temozolomide and Radiotherapy: Results of a Prospective Study.
- Source :
-
Neurologia medico-chirurgica [Neurol Med Chir (Tokyo)] 2015; Vol. 55 (9), pp. 749-55. Date of Electronic Publication: 2015 Sep 04. - Publication Year :
- 2015
-
Abstract
- Temozolomide (TMZ) as a concomitant and adjuvant chemotherapy to radiotherapy following maximal surgical resection is the established standard therapy for patients with newly diagnosed high-grade glioma. However, detailed analysis of chemotherapy-induced nausea and vomiting (CINV) associated with concomitant TMZ has not been sufficiently described. We prospectively analyzed the profile of CINV associated with concomitant TMZ. Eighteen consecutive patients with newly diagnosed high-grade glioma treated with concomitant chemoradiotherapy including TMZ were enrolled. CINV was recorded using a daily diary including nausea assessment, emetic episodes, degree of appetite suppression, and antiemetic medication use. The observed incidence rates of all grade nausea, moderate/severe (CTC grade 2, 3) nausea, emetic episodes, and appetite suppression for the overall period were 89%, 39%, 39%, and 83%, respectively. Moderate/severe nausea and severe (CTC grade 3) appetite suppression were frequently observed during the delayed phase of the treatment. Emetic episodes and moderate/severe nausea were significantly correlated with female gender. Moderate/severe nausea and severe appetite suppression were significantly correlated with low lymphocyte counts before chemoradiotherapy. For CINV associated with concomitant TMZ, enhanced antiemetic therapy focused on the delayed phase of the treatment will likely be beneficial, especially in female patients with a low lymphocyte count before chemoradiotherapy.
- Subjects :
- Adolescent
Adult
Aged
Antineoplastic Agents, Alkylating therapeutic use
Dacarbazine adverse effects
Dacarbazine therapeutic use
Female
Humans
Male
Middle Aged
Prospective Studies
Temozolomide
Young Adult
Antineoplastic Agents, Alkylating adverse effects
Chemoradiotherapy
Dacarbazine analogs & derivatives
Glioma therapy
Nausea chemically induced
Vomiting chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1349-8029
- Volume :
- 55
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Neurologia medico-chirurgica
- Publication Type :
- Academic Journal
- Accession number :
- 26345664
- Full Text :
- https://doi.org/10.2176/nmc.oa.2014-0413